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Analysis shows distinct biomarkers in post-hemorrhagic hydrocephalus and NMDAR encephalitis, indicating differing neuroinflammatory profiles.
PHH and NMDARE revealed distinct neuroinflammatory proteomic signatures compared to our control samples. PHH was marked by a broad increase in detection of the majority of inflammation-related proteins, with highest representation among the alternative complement and coagulation-related pathways. The persistent detection of these proteins for weeks after the initial hemorrhage may be indicative of chronic neuroinflammation, even at the time of permanent CSF diversion. Conversely, NMDARE induced a narrower lymphocyte-driven profile, more consistent with an antibody-mediated autoimmune disease. Furthermore, suppression of NELL2 and up-regulation of immunoglobulin-related markers (IGLC2, MZB1, CD79B) are potential candidates for biomarkers in PHH and NMDARE, respectively.
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Broudy et al. (2025) studied this question.
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