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December 10, 2025BMC Oral Health3 citationsOpen Access

Distinctive tumor biology of oral squamous cell carcinoma associated with oral submucous fibrosis and its suppressive immune microenvironment

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SSSenjeet SreekissoonDWDezhi WangYWYan Wang

Key Points

  • This research aims to explore the relationship between oral squamous cell carcinoma and oral submucous fibrosis, focusing on tumor behavior and immune microenvironment.
  • Examined tumor biology of oral squamous cell carcinoma (OSCC) associated with oral submucous fibrosis (OSF)
  • Analyzed immune microenvironment features using markers like IL-17, Treg cells, and PD-1/PD-L1
  • Performed comparative analysis of aggressive behavior and prognosis of OSCC with OSF versus OSCC alone.
  • OSCC with OSF exhibited more aggressive tumor biological behavior
  • Prognostic outcomes were worse in OSCC associated with OSF
  • The immune microenvironment was found to be more suppressive with elevated IL-17 and Treg cells, as well as increased PD-1/PD-L1 expression.

Abstract

OSCC with OSF displays more aggressive tumor biological behavior and worse prognosis, which contributed by a more suppressive immune microenvironment marked by elevated levels of IL-17, Treg cells, and PD-1/PD-L1 expression. These results highlight the need for tailored treatment approaches in managing OSCC in patients with OSF.

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Cite This Study

Sreekissoon et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f79d4https://doi.org/10.1186/s12903-025-07464-3
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