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December 10, 2025npj Imaging0 citationsOpen Access

89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4

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EGElizabeth GerminoRutgers, The State University of New JerseyKZKirstin A. ZettlitzCity of HopeTWTyler WatkinsCity Of Hope National Medical Center

Key Points

  • This research aims to characterize CD8+ T cell responses to cancer therapy using immunoPET.
  • Used anti-CD8 immunoPET for imaging immune responses.
  • Performed immunohistochemistry on tumor tissue samples.
  • Utilized an orthotopic mouse model of breast cancer.
  • Confirmed the presence of heterogeneous CD8+ T cell responses.
  • Documented an early immune response after combination treatment.
  • Imaging effectively detected these immune responses.

Abstract

Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8+ T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.

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Cite This Study

Germino et al. (2025) studied this question.

synapsesocial.com/papers/69401b312d562116f28f7b03https://doi.org/10.1038/s44303-025-00128-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer2015 · 2,441 citations
  2. 2An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy2015 · 331 citations
  3. 3Detection of antibody therapy-induced anti-tumor immune responses using anti-CD8 immuno-pet2015 · 4 citations
  4. 4Abstract 3577: A first assessment of CD8-PET/CT with 89Zr-Crefmirlimab as predictive biomarker for response to standard of care immunotherapy in patients with solid tumors2023 · 1 citations
  5. 5Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer2005 · 1,013 citations