Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells

In this study, we identified ceramides, a major class of sphingolipid metabolites, as a promising determinant in unequal biology and susceptibility to calcification of CA and AA. Our results reveal the previously unappreciated role of sphingolipid metabolism, particularly ceramides, in regional vascular pathology. These findings provide novel insights that inform our understanding of disease mechanisms and highlight potential ways for future therapeutic exploration.