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December 10, 2025PLoS GeneticsOpen Access

ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes

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Authors

WFWei FengZZZengming ZhangZCZeyu Chen

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Overview

Knockout of Asna1 impairs cardiac function and increases early mortality in mice, suggesting its role in cardiomyopathy.

Key Points

  • This research aims to explore the role of ASNA1 in cardiomyocytes and its link to cardiomyopathy.
  • Generated constitutive and inducible cardiomyocyte-specific Asna1 knockout mouse models.
  • Evaluated cardiac function following Asna1 deletion during embryogenesis and adulthood.
  • Conducted transcriptomic analyses to identify gene expression changes related to protein trafficking.
  • Perinatal lethality observed with constitutive Asna1 deletion during embryogenesis.
  • Inducible Asna1 knockout in adults resulted in rapid ventricular dilation and impaired cardiac function.
  • Transcriptomic analyses showed compensatory gene upregulation linked to disrupted vesicular transport.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/69401d412d562116f28f852dhttps://doi.org/10.1371/journal.pgen.1011964
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biallelic Variants in <i>ASNA1</i> , Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy2019 · 11 citations
  2. 2Cardiac α-Actin ( ACTC1 ) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy2019 · 55 citations
  3. 3Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency2021 · 54 citations
  4. 4Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy2024 · 2 citations
  5. 5SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity2025