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December 10, 2025Frontiers in GeneticsOpen Access

Adrenomedullin orchestrates treatment resistance in hepatocellular carcinoma via immune microenvironment remodeling

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Authors

XGXixi GaoYSYongliang SunJHJia Huang

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Overview

Integration of single-cell analyses reveals adrenomedullin as a prognostic biomarker in TACE-resistant hepatocellular carcinoma.

Key Points

  • This research aims to elucidate the role of adrenomedullin in treatment resistance within hepatocellular carcinoma.
  • Integrated single-cell RNA sequencing with bulk transcriptomic datasets
  • Utilized computational frameworks like scPAS and SCENIC
  • Conducted functional validation using Huh7 cellular models and xenograft systems
  • Performed mechanistic studies with Western blotting and quantitative reverse transcription polymerase chain reaction
  • Identified a TACE-resistant cell subset (scPAS+) linked to worse survival and treatment outcomes
  • Established adrenomedullin as a driver of treatment resistance and tumor aggressiveness
  • Demonstrated that ADM depletion improved sorafenib efficacy and reduced tumor burden

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/69401d472d562116f28f8608https://doi.org/10.3389/fgene.2025.1721263
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