Findings reveal IL-1β mediates immunosuppression by downregulating MHC-II in fibroblasts, highlighting the tumor microenvironment's role.
Our study identifies an IFN-γ/STAT1/CIITA axis as the central regulator of MHC-II expression in fibroblasts and reveals IL-1β as a potent suppressor of this pathway. These findings highlight a novel cytokine-mediated regulatory mechanism underlying CAF-driven immunosuppression within the tumor microenvironment.
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Chen et al. (2025) studied this question.
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