Atroposelective Synthesis of Barbiturate Substituted Chiral Styrenes

Manju Devi; Navya Gupta; Ravi P. Singh

doi:10.1039/d5cc06302g

December 9, 2025Chemical Communications

Atroposelective Synthesis of Barbiturate Substituted Chiral Styrenes

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Key Points

To report the enantioselective synthesis of axially chiral barbiturate-substituted styrenes.
Used vinylidene ortho-quinone methide (VQM) derived from 1-alkynylnaphthalen-2-ols.
Employed 5-substituted barbituric acids for synthesis.
Utilized quinidine-based organocatalyst for the reaction.
Synthesis of axially chiral barbiturate-substituted styrenes was successfully achieved.
Demonstrated high enantioselectivity in the presented method.

Implication

Enantioselective synthesis of axially chiral barbiturate-derived styrenes from VQM, suggesting new synthetic pathways.

Abstract

Herein, the first report on enantioselective synthesis of axially chiral barbiturate-substituted styrenes is disclosed from vinylidene ortho-quinone methide (VQM) derived from 1-alkynylnaphthalen-2-ols and 5-substituted barbituric acids using quinidine-based organocatalyst. This...

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Cite This Study

Devi et al. (2025) studied this question.

synapsesocial.com/papers/69401d5b2d562116f28f8d1f https://doi.org/10.1039/d5cc06302g

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Atroposelective Synthesis of Barbiturate Substituted Chiral Styrenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Atroposelective Synthesis of Barbiturate Substituted Chiral Styrenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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