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December 9, 2025Chinese Journal of ChemistryOpen Access

Stable π‐Stacked Perylenediimide Radical Dimers for Efficient Photothermal Therapy

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Authors

YZY. L. ZhangLZLe ZhangHZHeng Zhang

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Overview

Innovative metallacycle design improves photothermal conversion efficiency in radical anions, suggesting enhanced therapeutic applications.

Key Points

  • To develop stable Perylenediimide (PDI) radical dimers for better photothermal therapy.
  • Developed a π-stacked PDI dimer using an N‐heterocyclic carbene metallacycle.
  • Reduced the dimer to a PDI radical dimer using glutathione.
  • Conducted in vitro and in vivo experiments to assess therapeutic efficacy.
  • Achieved a photothermal conversion efficiency of 84.9%, 13.1 times higher than monomeric PDI radical anion.
  • Demonstrated robust ambient stability for over 30 days.
  • Showed good biocompatibility and effective photothermal therapeutic efficacy in tumor cells.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8da8https://doi.org/10.1002/cjoc.70348
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