⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

December 9, 2025Chemical Communications

An ROS/viscosity dual-activated nanoprobe with CD44-targeting ability for NIR-II imaging of early atherosclerotic plaques

Shuai Zhao Ruixin Liu Yanxiang Gao Yike Li Wenjing Wang Jingang Zheng Fang Sun Jun Nie Yincheng Chang

View at Publisher

Ask AI

Bookmark

Share

Key Points

The aim is to develop a nanoprobe for targeted imaging of atherosclerotic plaques using dual activation.
Designed a DCy-BOH@BSA-HA nanoprobe to be activated by reactive oxygen species and viscosity.
Targeted CD44 receptors on atherosclerotic plaques for enhanced imaging.
Used NIR-II imaging technologies for visualization of early-stage plaques.
The nanoprobe successfully targeted atherosclerotic plaques in early stages.
Activation by ROS and viscosity improved imaging efficacy.
Demonstrated potential for advanced diagnostic methods in cardiovascular diseases.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Implication

Nanoprobe demonstrates targeted imaging of atherosclerotic plaques, implying potential for early disease detection.

Abstract

A DCy-BOH@BSA-HA nanoprobe can be activated by ROS/viscosity and target atherosclerotic plaques for NIR-II imaging.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8e14 https://doi.org/10.1039/d5cc05890b

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Cascade‐Activatable Nanoprobes for NIR‐II Fluorescence/Photoacoustic Dual‐Modal Imaging of Atherosclerotic PlaquesRandomized Controlled Trial · 2026
2Diagnosis and Vulnerability Risk Assessment of Atherosclerotic Plaques Using an Amino Acid-Assembled Near-Infrared Ratiometric Nanoprobe2024 · 3 citations
3Cholesterol-Anchored AND-Logic NIR-II Probe for Triple-Responsive Atherosclerosis Imaging2025 · 4 citations
4Near-Infrared Persistent Luminescence Nanoprobe for Early Detection of Atherosclerotic Plaque2024 · 47 citations
5An “AND” Logic Gated Near-Infrared Fluorescent Probe Simultaneously Sensing Superoxide Anion and Viscosity Enables Early Atherosclerosis MonitoringOriginal Research · 2026
6Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system2024 · 14 citations
7<em>In vivo</em> Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosisother · 2011 · 32 citations
8Exosome‐Engineered Afterglow Probe for Targeted Imaging of Atherosclerotic Plaques In Vivo2025 · 3 citations
9Light-activated thiomaleimide crosslinking stabilizes collagen mimetic peptide triple helixChemical Communications · 2026
10Macrocyclic stibine-bridged [1.1.1] and [1.1.1.1] ferrocenophanesChemical Communications · 2026

More from Chemical Communications

More from Chinese Academy of Medical Sciences & Peking Union Medical College

More from Beijing University of Chemical Technology

More from China-Japan Friendship Hospital