Synthesis of a mitochondria-targeted ruthenium complex shows enhanced photocytotoxicity in photodynamic therapy, indicating improved treatment potential.
We report the synthesis of a mitochondria-targeted binuclear [Ru(bpy) 2 (S 2 C(C 4 H 8 N 2 )CS 2 )Ru(bpy) 2 ](PF 6 ) 2 (Ru1) complex, with a significant bathochromic absorbance shift, photocytotoxicity via type I/II PDT, when compared with mononuclear [Ru(bpy) 3 ]Cl 2 .
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Negi et al. (2025) studied this question.
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