Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Edina Pandur; L. Heilmann; Margita Utczás; Tibor Rák; Katalin Sipos; Adrienne Csutak; Györgyi Horváth

doi:10.1186/s12906-025-05215-z

December 9, 2025BMC Complementary Medicine and TherapiesOpen Access

Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

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Key Points

The aim is to evaluate the neuroprotective effects of sweet orange essential oil and (+)-limonene in neurodegeneration models.
Used differentiated SH-SY5Y neuroblastoma and BV-2 microglia co-culture models
Assessed oxidative stress, inflammation, and apoptosis levels
Monitored neuroprotective effects of sweet orange EO and (+)-limonene
Sweet orange EO and (+)-limonene significantly reduced oxidative stress
Marked decrease in inflammation and apoptosis observed
Proposed as effective neuroprotective agents for Parkinson's disease

Implication

Experiment shows oxidative stress and inflammation reduce in neuroblastoma models with sweet orange EO and limonene, suggesting neuroprotective effects for Parkinson's disease.

Abstract

Based on these results, sweet orange EO and its main component, (+)-limonene, can be considered as neuroprotective agents and are promising candidates for complementary therapy in Parkinson's disease.

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Cite This Study

Pandur et al. (2025) studied this question.

synapsesocial.com/papers/69401d682d562116f28f918f https://doi.org/10.1186/s12906-025-05215-z

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Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Key Points

Implication

Abstract

Discussion

Cite This Study

Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Key Points

Implication

Abstract

Discussion

Cite This Study

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