Single-cell analysis reveals oxidative stress and microglia dysfunction contribute to PD-like pathology in C57BL/6 mice, suggesting a need for ATZ guideline re-evaluation.
Environmental ATZ exposure triggers PD-like neurodegeneration through dual mechanisms: (1) neuronal calcium dysregulation inducing oxidative stress and (2) microglia-driven neuroimmune dysfunction via CX3CL1 signaling. This study provides the novel mechanistic evidence linking ATZ to PD-like pathology via neuron-microglia crosstalk, highlighting the need for re-evaluating global ATZ exposure guidelines.
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Zhou et al. (2025) studied this question.
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