Replicative study of the involvement of long non-coding RNA genes in the manifestation of antisocial behavior

Objective. To perform replicative analysis of gene loci associated with the risk of antisocial behavior (AB) in European cohorts and the manifestation of extreme forms of AB (murder), considering ethnicity in the Russian sample. Material and methods. Two groups of individuals were examined: those with AB (n=227) and the control group (n=254), using logistic regression, in which genetic profile data as well as social and demographic parameters were used as independent variables. Results. Associations of the rs4714329*G/G variants in the LINK00951 gene (OR=2.92, p=0.006), rs7232069*G variants in the LINK00907 gene (OR=2.0, p=0.006), and rs12977121*A/A variants in the CSNK1G2 gene (OR=1.76, p=0.044) were confirmed with an increased risk of AB among Russians. A significant effect of tobacco smoking on the association of the CSNK1G2 gene locus was found: a higher risk of manifestation of AB extreme forms was observed in persons with nicotine dependence, carriers of the rs12977121*A/A genotype (OR=3.63, p=0.001). Conclusion. The data obtained indicate the potential involvement of long non-coding RNA and casein kinase genes in the development of aggressiveness.