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December 9, 2025New England Journal of Medicine34 citations

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

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JCJonathan D. CaseyKSKevin P. SeitzBDBrian E. Driver

Key Points

  • To compare the effects of ketamine and etomidate on in-hospital death rates during tracheal intubation in critically ill adults.
  • Randomised trial comparing ketamine and etomidate for anesthesia induction.
  • Population included critically ill adults undergoing tracheal intubation.
  • Outcomes assessed included in-hospital death by day 28.
  • No significant difference in in-hospital death rates between ketamine and etomidate by day 28.

Abstract

Among critically ill adults undergoing tracheal intubation, the use of ketamine to induce anesthesia did not result in a significantly lower incidence of in-hospital death by day 28 than etomidate. (Funded by the Patient-Centered Outcomes Research Institute and others; RSI ClinicalTrials.gov number, NCT05277896.).

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Cite This Study

Casey et al. (2025) studied this question.

synapsesocial.com/papers/69401ef02d562116f28f95c6https://doi.org/10.1056/nejmoa2511420
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