What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To compare the effects of ketamine and etomidate on in-hospital death rates during tracheal intubation in critically ill adults.

December 9, 2025

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

Puntos clave

To compare the effects of ketamine and etomidate on in-hospital death rates during tracheal intubation in critically ill adults.
Randomised trial comparing ketamine and etomidate for anesthesia induction.
Population included critically ill adults undergoing tracheal intubation.
Outcomes assessed included in-hospital death by day 28.
No significant difference in in-hospital death rates between ketamine and etomidate by day 28.

Resumen

Among critically ill adults undergoing tracheal intubation, the use of ketamine to induce anesthesia did not result in a significantly lower incidence of in-hospital death by day 28 than etomidate. (Funded by the Patient-Centered Outcomes Research Institute and others; RSI ClinicalTrials.gov number, NCT05277896.).

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