We present the case of a 54-year-old male with relapsing multiple myeloma (MM) complicated by biopsy-proven amyloid deposition, monitored over a span of 13 years with serial 18F-FDG PET/CT imaging. The patient experienced multiple treatment interruptions and disease relapses, with evolving imaging features ranging from widespread skeletal involvement to soft tissue plasmacytoma formation and associated amyloid deposition. This case highlights the evolving role of 18F-FDG PET/CT in detecting disease progression and treatment response in plasma cell dyscrasias with coexisting amyloidosis.
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Dikshit et al. (2025) studied this question.
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