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December 8, 2025Biotechnic & Histochemistry

Stereological analysis of spleen alterations in streptozotocin–nicotinamide-induced diabetic rats

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Authors

TLTeresa LucretiaCACherry AzariaIIImelda Imelda

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Overview

Stereological analysis reveals immune responses and spleen atrophy in diabetic rats after hyperglycemia, indicating disease progression.

Key Points

  • Spleen atrophy correlates with body weight loss in diabetic rats, underscoring disease severity.
  • Elevated inflammatory responses were observed, notably with polymorphonuclear leukocyte infiltration at 5 weeks post-induction.
  • Histological evaluations and stereological methods were utilized to assess spleen alterations.
  • Findings highlight a shift from inflammation to atrophy in spleen structure as diabetes progresses.

Cite This Study

Lucretia et al. (2025) studied this question.

synapsesocial.com/papers/69401f062d562116f28f9e38https://doi.org/10.1080/10520295.2025.2587290
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