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December 8, 2025Frontiers in PsychiatryOpen Access

Association between olanzapine and immune function in lung cancer patients with anxiety and depression: a retrospective cohort study of medical records

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Authors

SCShang ChenNanchang UniversityGHGelun HuangSun Yat-sen UniversitySLSen LeiSun Yat-sen University

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Implication

Retrospective cohort study shows olanzapine enhances immune function in lung cancer patients with anxiety and depression, suggesting its role in cancer immunotherapy.

Key Points

  • Olanzapine treatment enhanced immune function by increasing CD3, CD4, and NK cell counts while lowering Neutrophil-to-Lymphocyte Ratio.
  • Lung cancer patients with anxiety and depression showed significantly altered lymphocyte subsets, indicating compromised immune function.
  • Assessment of anxiety and depression utilized Self-Rating Anxiety Scale and Self-Rating Depression Scale, with notable reductions post-olanzapine therapy.
  • Study results suggest olanzapine could serve as an adjunct in cancer immunotherapy, improving both psychological and immune health.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69401f062d562116f28f9e78https://doi.org/10.3389/fpsyt.2025.1655599
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Also Consider

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