Observational analysis improves regulatory T cells and reduces CD8+ T cells in collagen induced arthritis, suggesting enhanced therapy with MSCs expressing mutant IL-2.
Mutant IL-2 enhances Treg function and proliferation while exerting reduced effects on CD8⁺ T and NK cell activation. MSC expressing mutant IL-2 demonstrates therapeutic benefits in CIA by increasing the proportion of Treg cells and reducing the proportion of CD8⁺ T cells.
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Tang et al. (2025) studied this question.
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