Systematic review demonstrates efficacy of low-flow settings for acute exacerbations of COPD, suggesting improved outcomes.
HFNC_Low demonstrates superior efficacy in lowering PaCO₂ levels, the incidence of nasal and facial injuries, and improving pH. Although HFNC_Mod may reduce hospital stay, low-flow settings are recommended as the preferred initial strategy for AECOPD.
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Ding et al. (2025) studied this question.
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