Novel amphiphilic copolymers as stabilizers for glyceryl monooleate-based lipid–polymer hybrid nanoparticles

Theodore Sentoukas; Kamil Dawid; Katarzyna Filipek; Maria Chountoulesi; Magdalena Górniewicz; Stergios Pispas; Urszula Szeluga

doi:10.1039/d5sm00831j

December 8, 2025Soft Matter

Novel amphiphilic copolymers as stabilizers for glyceryl monooleate-based lipid–polymer hybrid nanoparticles

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Key Points

Lipids-polymer hybrid nanoparticles exhibited favorable physicochemical characteristics, enhancing stability.
Key metrics include detailed analysis through advanced microscopy and thermal characterization techniques.
Assessment using DLS and cryo-TEM confirmed the morphological stability of the nanoparticles under varied conditions.
This work supports the potential for improved delivery systems in therapeutic applications with lipid-polymer hybrids.

Implication

Analysis highlights physicochemical characteristics of lipid-polymer hybrid nanoparticles using cryo-TEM and FFT.

Abstract

In this study lipid-polymer nanosystems were prepared by the top-down method. Their physicochemical and morphological characteristics were assessed through DLS, cryo-TEM, FFT and mDSC.

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Cite This Study

Sentoukas et al. (2025) studied this question.

synapsesocial.com/papers/69401f0f2d562116f28fa18e https://doi.org/10.1039/d5sm00831j

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Novel amphiphilic copolymers as stabilizers for glyceryl monooleate-based lipid–polymer hybrid nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel amphiphilic copolymers as stabilizers for glyceryl monooleate-based lipid–polymer hybrid nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

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