Scoping review finds low vitamin D levels increase chemotherapy-induced peripheral neuropathy incidence in cancer patients, suggesting nutritional status matters.
Key Points
Higher incidence of CIPN occurs in patients with low vitamin D levels during cytotoxic chemotherapy, particularly with paclitaxel.
Observational studies reveal significant association between low serum vitamin D and CIPN severity in cancer treatments involving vinca alkaloids and taxanes.
Findings highlight the potential neuroprotective role of vitamin D in mitigating chemotherapy-induced peripheral neuropathy risks.
Future research should validate vitamin D cutoffs and explore mechanisms linking nutritional status to CIPN outcomes.
Cite This Study
Duarte-Zambrano et al. (2025) studied this question.