December 8, 2025Aesthetic Plastic SurgeryOpen Access

Efficacy of Ionization-Adjusted PN Filler in Minimizing Injection Pain: A Randomized, Patient-Blinded, Split-Face Study

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Discussion

Randomized, patient-blinded trial shows ionized filler reduces pain while maintaining clinical efficacy and safety.

Ionized PN filler reduced pain scores compared to conventional filler, with a VAS score of 3.39 vs 5.04.
Pain assessment utilized a 10-point Visual Analog Scale, indicating a significant decrease in discomfort.
Findings stem from a randomized, patient-blinded, split-face study involving 15 participants.
Clinical efficacy remained similar for both fillers, suggesting comparable safety profiles without significant trade-offs.

Park et al. (2025) studied this question.

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