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December 8, 2025British Journal of HaematologyOpen Access

A high‐throughput bone marrow 3D co‐culture system to study resistance to BCR signalling targeted agents in B‐ NHL

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Authors

AZAlex ZadroAAAlberto J. ArribasMCMaria Vittoria Colombo

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Overview

Automated 3D co-culture demonstrates therapeutic resistance in B-NHL lymphoma cells, suggesting new strategies for treatment.

Key Points

  • Lymphoma cell resistance to inhibitors was decreased in the bone marrow microenvironment.
  • 3D co-culture model replicates interactions that affect drug sensitivity in B-NHL.
  • Analysis of stromal interactions highlights the role of therapeutic resistance mechanisms.
  • Personalized strategies may be enabled through insights gained from this automated model.

Cite This Study

Zadro et al. (2025) studied this question.

synapsesocial.com/papers/694020d72d562116f28fa8e7https://doi.org/10.1111/bjh.70273
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