Case report shows altered pharmacokinetics of cefazolin during kidney replacement therapy in critically ill patients, suggesting tailored dosing may be essential.
Acute kidney injury is a frequent complication in critically ill patients and often necessitates kidney replacement therapy. Optimising antimicrobial dosing in this population is essential yet challenging owing to altered pharmacokinetics in critical illness and the wide variability of prescriptions utilised in kidney replacement therapy. This case report investigates the pharmacokinetics of cefazolin in a critically ill patient receiving prolonged intermittent kidney replacement therapy, offering insights into dosing considerations in this clinical setting.
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Salman et al. (2025) studied this question.
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