Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction

Weixing Dai; Wenqin Luo; Hong-Sheng Fang; Guoxiang Cai; Yikuan Chen; Senlin Zhao; Renjie Wang

doi:10.1186/s12964-025-02569-2

December 8, 2025Cell Communication and SignalingOpen Access

Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction

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Key Points

Peritoneal metastasis was significantly promoted by cancer-associated adipocyte signaling, indicating its crucial role.
The study reveals that FABP4 serves as a therapeutic target in colorectal signet ring cell carcinoma with high aggressiveness.
Analysis of exosomal signaling involved fatty acid metabolic reprogramming that contributes to cancer aggressiveness.
This finding highlights the potential for targeting FABP4 to combat metastasis and improve treatment strategies.

Implication

Cancer-associated adipocyte signaling enhances aggressiveness and points to FABP4 as a therapeutic target for peritoneal metastasis.

Abstract

CAA-derived exosomal signaling promotes SRCC aggressiveness through FABP4-mediated fatty acid metabolic reprogramming, identifying FABP4 as a potential therapeutic target for peritoneal metastasis in colorectal SRCC.

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Cite This Study

Dai et al. (2025) studied this question.

synapsesocial.com/papers/694020e22d562116f28fa9a4 https://doi.org/10.1186/s12964-025-02569-2

View Full Paper

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Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction

Key Points

Implication

Abstract

Discussion

Cite This Study

Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction

Key Points

Implication

Abstract

Discussion

Cite This Study

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