Experimental analysis reveals KLF10-IN-1 reduces apoptosis in retinal cells, suggesting its potential benefits for diabetic retinopathy treatment.
KLF10 is upregulated in DR model mice and high-glucose/hypoxia-exposed RPE cells and modulates apoptosis and ER stress through the PERK/eIF2α/ATF4/CHOP pathway. KLF10-IN-1 has protective effects, suggesting its potential for early DR treatment.
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Hu et al. (2025) studied this question.
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