December 6, 2025Communications BiologyOpen Access

IFN-γ and IL-17 elicit synergistic anti-mycobacterial responses by inhibiting coronin-1A retention

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Study finds IL-17 and IFN-γ enhances Mycobacterium tuberculosis killing in macrophages, suggesting new tuberculosis treatment avenues.

IL-17 and IFN-γ co-treatment significantly reduces Mycobacterium tuberculosis load in macrophages and tissues.
This response involves cytokines modulating phosphorylation of STAT1 and targeting phagosome retention.
Mechanistic analysis reveals that interaction leads to enhanced phagolysosomal fusion, crucial for bacterial killing.
Research supports exploring IL-17 therapies alongside traditional tuberculosis treatments for improved efficacy.

Park et al. (2025) studied this question.

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