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December 6, 2025AllergyOpen Access

Mediation of Polygenic Asthma Risk Through Gene Expression

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Authors

RNRama NatarajanBSBrooke SzczesnyMBMeher Preethi Boorgula

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Overview

Analysis finds gene expression mediates asthma risk in African ancestry, suggesting new biomarker pathways.

Key Points

  • Asthma risk is influenced by gene expression and eiosinophils, supporting known biology of the condition.
  • Eosinophils play a significant role in mediating the relationship between gene expression and asthma.
  • Research utilized polygenic risk scores from the PGS Catalog across African-ancestry populations to evaluate mediation.
  • Findings suggest potential for using biomarkers in asthma risk assessment and management, highlighting clinical applications.

Cite This Study

Natarajan et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb559https://doi.org/10.1111/all.70101
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