Observational analysis shows improved metabolic stability in C57BL/6J mice, indicating PET imaging requires early monitoring.
N-[¹¹C]methyl-(R)-JNJ-31020028 binds selectively to NPY2R but undergoes rapid metabolism and strong P-gp-mediated efflux at the murine blood-brain barrier. Reliable data interpretation requires early imaging and metabolite correction. For preclinical NPY2R-PET, pharmacological P-gp inhibition may be essential, and future tracers should be optimized for improved metabolic stability.
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Fernandes et al. (2025) studied this question.
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