Synthesis of chiral cyclohexanol derived benzylamines, applications for enantiodiscrimination of optically active analytes by NMR spectroscopy

Binal B. Parmar; Ray J. Butcher; Ashutosh V. Bedekar

doi:10.1039/d5nj02505b

December 5, 2025New Journal of Chemistry

Synthesis of chiral cyclohexanol derived benzylamines, applications for enantiodiscrimination of optically active analytes by NMR spectroscopy

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Key Points

Chiral cyclohexanol benzylamines enhance chiral discrimination of optically active analytes by NMR.
Prepared pairs of diastereomeric chiral solvating agents led to improved enantiodiscrimination efficacy.
Synthesis of these chiral agents allows for advanced NMR techniques in chemical analysis.
The findings highlight the importance of chiral speciation in enhancing NMR spectroscopy applications.

Implication

Synthesis reveals chiral cyclohexanol benzylamines improve enantiodiscrimination of analytes by NMR spectroscopy.

Abstract

Cyclohexanol derived benzyl amines are synthesized and scanned as Chiral Solvating Agents (CSA) for chiral discrimination of optically active analytes by NMR analysis. A pair of diastereomeric CSAs is prepared...

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Cite This Study

Parmar et al. (2025) studied this question.

synapsesocial.com/papers/6940224e2d562116f28fbffa https://doi.org/10.1039/d5nj02505b

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Synthesis of chiral cyclohexanol derived benzylamines, applications for enantiodiscrimination of optically active analytes by NMR spectroscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of chiral cyclohexanol derived benzylamines, applications for enantiodiscrimination of optically active analytes by NMR spectroscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

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