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December 5, 2025BMC CancerOpen Access

Concurrent genomic assessment of circulating tumour cells and ctDNA to guide therapy in metastatic breast cancer

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Authors

RARebecca C. AllsoppEWEvie WrenGNGeorgios Nteliopoulos

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Overview

Observational analysis provided genomic information in metastatic breast cancer, indicating CTCs may guide personalised medicine effectively.

Key Points

  • CTCs revealed critical genomic information missed by ctDNA, enhancing treatment options.
  • Majority of samples showed complementary genomic data using blood from 8 patients for analysis.
  • Blood sampling captured CTCs and cfDNA via established techniques, facilitating genomic profiling.
  • Results highlight the potential of CTCs in monitoring HER2 status, supporting treatment decisions.

Cite This Study

Allsopp et al. (2025) studied this question.

synapsesocial.com/papers/694022532d562116f28fc217https://doi.org/10.1186/s12885-025-15187-5
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