Examining functional connectivity in metabolic syndrome and small vessel disease: A novel approach to understanding olfactory dysfunction and Alzheimer’s disease

Hector Reyes; Jaime D. Mondragón; Conner Frank; Claire Murphy

doi:10.1016/j.brainres.2025.150084

December 2, 2025Brain ResearchOpen Access

Examining functional connectivity in metabolic syndrome and small vessel disease: A novel approach to understanding olfactory dysfunction and Alzheimer’s disease

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Key Points

Neural alterations in the cognitive control networks affect olfactory dysfunction, indicating cardiovascular risks for brain health.
Alterations in functional connectivity among key networks were identified in participants with metabolic syndrome and small vessel disease.
Observational analysis of neural patterns associated with Alzheimer's disease suggests early indicators of cognitive decline related to vascular health risks.
Findings imply early detection of dementia could improve through the recognition of cardiovascular risk factors affecting brain connectivity.

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Abstract

These findings highlight distinct neural alterations in olfactory and cognitive control networks associated with cardiovascular risk factors, providing novel insights into early brain changes linked to cardiovascular risk factors for dementia.

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Reyes et al. (2025) studied this question.

synapsesocial.com/papers/694025972d562116f28fed10 https://doi.org/10.1016/j.brainres.2025.150084

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Examining functional connectivity in metabolic syndrome and small vessel disease: A novel approach to understanding olfactory dysfunction and Alzheimer’s disease

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Examining functional connectivity in metabolic syndrome and small vessel disease: A novel approach to understanding olfactory dysfunction and Alzheimer’s disease

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

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