December 2, 2025The Journal of Steroid Biochemistry and Molecular BiologyOpen Access

Alterations of vitamin D metabolism and requirements in clinical conditions with impaired gastro-intestinal and renal function and in critical illness

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Authors

ISInez SchoenmakersUniversity of East Anglia AFAlastair ForbesUniversity of East Anglia KJKerry S. JonesBridge University

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Implication

Narrative review highlights vitamin D metabolism alterations in critical illness and chronic kidney disease, suggesting dietary adjustments are necessary for improved bioavailability and immune health

Key Points

Gastro-intestinal inflammation reduces vitamin D bioavailability, leading to potential health issues.
A focus on vitamin D binding protein highlights its impact on immune response and metabolism.
Renal impairment disrupts vitamin D metabolism, notably affecting its hydroxylation to bioactive forms.
Understanding the interplay between organ function and vitamin D dynamics is crucial for patient management.

Cite This Study

Schoenmakers et al. (2025) studied this question.

synapsesocial.com/papers/6940274a2d562116f28ff5f6 https://doi.org/10.1016/j.jsbmb.2025.106909

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Alterations of vitamin D metabolism and requirements in clinical conditions with impaired gastro-intestinal and renal function and in critical illness

Discussion

Member takes

Implication

Key Points

Cite This Study

Alterations of vitamin D metabolism and requirements in clinical conditions with impaired gastro-intestinal and renal function and in critical illness

Discussion

Member takes

Implication

Key Points

Cite This Study

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