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Findings demonstrate probiotics enhance macrophage function, indicating a novel mTORC1-HDAC pathway in gut immunity.
Collectively, mTORC1-HDAC3/8-H4K31Cr pathway is a key mechanism by which butyrate-producing commensal bacteria enhance immune defense in gut. This discovery provides a novel foundation for the screening and application of the next generation of butyrate-producing probiotics. Video Abstract.
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Wu et al. (2025) studied this question.
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