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Research Paper | Synapse

December 1, 2025The Journal of Heart and Lung Transplantation0 citationsOpen Access

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Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia–reperfusion

RKRachel KleinSt. Joseph's Hospital and Medical Center JBJonathan BraatNorthwestern University RBRoss M. BremnerCreighton University

Key Points

Neutrophils are significantly implicated in influencing early lung allograft outcomes.
Key metrics show a correlation between neutrophil levels and injury severity in lung ischemia-reperfusion.
Observational analysis across various cases highlights the G-CSF-immature neutrophil axis as a potential target for intervention.
Understanding neutrophil heterogeneity in the perioperative setting may enable better clinical strategies for lung transplants.

Abstract

Our findings underscore the clinical significance of neutrophil heterogeneity in the early perioperative setting following LTx. Targeting the G-CSF-immature neutrophil axis may offer a novel strategy to improve early lung allograft outcomes.

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Cite This Study

Klein et al. (Mon,) studied this question.

synapsesocial.com/papers/694028d52d562116f2900af5 https://doi.org/https://doi.org/10.1016/j.healun.2025.11.030

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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2Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes—A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation2017 · 192 citations
3Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease2010 · 437 citations
4Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: Definition and grading—A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation2017 · 704 citations
5Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-192022 · 33 citations