December 1, 2025Organic & Biomolecular Chemistry

Direct α-halogenation of carboxylic acids with N -bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H ₂ SO ₄

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Alpha-halogenation of carboxylic acids occurred with N-bromosuccinimide and trichloroisocyanuric acid, demonstrating effective halogenation.
Key evidence includes the use of N-bromosuccinimide and trichloroisocyanuric acid as halogenating agents in the reaction.
Direct halogenation method employed N-bromosuccinimide or trichloroisocyanuric acid under acidic conditions with a catalyst.
The findings highlight potential efficiency and conditions for α-halogenation using carboxylic acids and halogenating agents.

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Implication

Assessment shows enhanced α-halogenation of carboxylic acids using N-bromosuccinimide and trichloroisocyanuric acid, indicating efficient catalytic conditions.

Cite This Study

Tanemura et al. (2025) studied this question.

synapsesocial.com/papers/69402a6b2d562116f2901bd6 https://doi.org/10.1039/d5ob01483b

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Implication

Assessment shows enhanced α-halogenation of carboxylic acids using N-bromosuccinimide and trichloroisocyanuric acid, indicating efficient catalytic conditions.

Direct α-halogenation of carboxylic acids with N -bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H ₂ SO ₄

Key Points

Discussion

Implication

Cite This Study

Direct α-halogenation of carboxylic acids with N -bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H ₂ SO ₄

Key Points

Discussion

Implication

Cite This Study

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