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Case highlights micrometastases development post-negative sentinel lymph node biopsy in high-risk melanoma patients, suggesting importance of diligent follow-up.
Melanoma is an aggressive skin cancer with high mortality, particularly when not detected early. We present a case of metastatic melanoma in a patient with primary invasive melanoma and a negative sentinel lymph node biopsy who was lost to follow-up. Despite initial negative nodal involvement, the patient later developed head and neck micrometastases, resembling a “buckshot” pattern. We review current sentinel lymph node biopsy guidelines relative to tumor stage and recurrence risk. This case underscores the importance of diligent follow-up in high-risk melanoma patients, even after a negative sentinel lymph node biopsy.
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Werpachowski et al. (2025) studied this question.
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