Systematic review shows that radiosurgical management improves prognosis and safety in low-grade gliomas, implying the importance of molecular classification evidence.
SRS offers a non-invasive management option for selected LGGs with durable control and acceptable safety. Prognosis appears to be influenced by treatment history, including prior radiotherapy and surgical management. Lack of molecular stratification highlights the need for studies focused on IDH (isocitrate dehydrogenase)-mutant LGGs to clarify the role of SRS in the molecular era.
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Mizutani et al. (2025) studied this question.
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