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November 27, 2025Malaria JournalOpen Access

The pattern of gene amplification of members of the Plasmodium vivax erythrocyte binding-like proteins family across the Amazon rainforest

Karla de Sena Guedes Gabriela M. Fernandes Bruno A. M. Sanchez John H. Adams Flora Satiko Kano Cor Jésus Fernandes Fontes Taís Nóbrega de Sousa Luzia H. Carvalho

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Abstract

This study identifies dbp and ebp2 gene amplifications in P. vivax isolates from the Amazon rainforest, with regional CNV variation but no association with any DARC-positive genotype. These findings support further investigation into gene amplifications to elucidate their biological and immunological significance in DARC-positive populations.

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Cite This Study

Guedes et al. (2025) studied this question.

synapsesocial.com/papers/694030052d562116f2905ba6 https://doi.org/10.1186/s12936-025-05690-2

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Natural genetic diversity of the DBL domain of a novel member of the Plasmodium vivax erythrocyte binding-like proteins (EBP2) in the Amazon rainforest2024 · 3 citations
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