Penile melanoma is a rare neoplasm with aggressive biological behaviour and a dismal prognosis. We report the case of a 65-year-old male with a pigmented nodular lesion on the glans. Histopathology confirmed the diagnosis of penile melanoma with adverse prognostic features. Lymph node involvement was already present at diagnosis. He underwent partial penectomy and robotic-assisted laparoscopic bilateral inguinal and pelvic lymph node dissection, following confirmation of lymphatic spread by fine needle aspiration cytology. Thereafter, he received adjuvant radiotherapy and was started on nivolumab. This case highlights the importance of multimodal treatment, with no recurrence after 15 months of follow-up.
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Gil et al. (2025) studied this question.
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