Trophoblast cell surface antigen 2 (TROP2) from ascitic extracellular vesicles drives peritoneal metastasis of ovarian cancer by mesothelial-to-mesenchymal transition

This study is the first to identify the pivotal role of TROP2 from ascitic EV in promoting metastatic dissemination by activating the TNF-α/NF-κB signaling axis. By remodeling the peritoneal microenvironment, TROP2 facilitates metastatic spread. These findings provide novel molecular insights into the mechanism of ovarian cancer peritoneal metastasis and offer significant implications for clinical translation.