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November 26, 2025JAMA Ophthalmology

Contrast Sensitivity in Ultra-Thin DSAEK vs DMEK

Charles C. Lin Elaine Tran Winston D Chamberlain Xiangxue Xiao Tom Lietman Jennifer Rose-Nussbaumer

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Abstract

This secondary analysis of the Descemet Endothelial Thickness Comparison Trial Therapeutic Exploratory Study (DETECT-TES) randomized clinical trial investigates the contrast sensitivity between Descemet membrane endothelial keratoplasty (DMEK) and ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK).

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Lin et al. (2025) studied this question.

synapsesocial.com/papers/694035f62d562116f2909389 https://doi.org/10.1001/jamaophthalmol.2025.4807

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Contrast Sensitivity in Ultra-Thin DSAEK vs DMEK2025
2Ultrathin DSAEK versus DMEK – Review of systematic reviewsMeta-Analysis · 2023 · 7 citations
3Descemet Endothelial Thickness Comparison Trial II (DETECT II): multicentre, outcome assessor-masked, placebo-controlled trial comparing Descemet membrane endothelial keratoplasty (DMEK) to Descemet stripping only (DSO) with adjunctive ripasudil for Fuchs dystrophy2024 · 8 citations
4Clinical Outcomes After Ultrathin Descemet Stripping Automated Endothelial Keratoplasty Versus Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy: A Systematic Review and Meta-AnalysisMeta-Analysis · 2026
5Optical quality after ultrathin Descemet’s stripping automated endothelial keratoplasty and Descemet’s membrane endothelial keratoplasty: a randomised controlled clinical trial2025