Collectively, our findings establish miR-188-5p as a ferroptosis driver in IDD. Knockdown of miR-188-5p significantly upregulated P4HB expression, suppressed ferroptosis, and attenuated IDD progression. This study identifies miR-188-5p as a potential therapeutic target, providing a novel mechanistic framework for IDD treatment strategies.
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Yan et al. (2025) studied this question.
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