Network meta-analysis shows reduced risk of CIN2+ lesions and anogenital warts in vaccinated individuals, indicating clinical efficacy against pre-cancers without safety concerns.
The evidence in this network meta-analysis of HPV vaccines is based on extensive searches and analyses. There is evidence from randomised controlled trials that HPV vaccination reduces the risk of pre-cancerous outcomes such as CIN2+ and anogenital warts. No data were available for cervical cancer or other cancer outcomes, and no data on pre-cancer outcomes were available for vaccination under age 15 years. There were no safety concerns noted in the studies.
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Bergman et al. (2025) studied this question.
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