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The present study suggests that GLP-1RA may be the optimal treatment for NAFLD patients. In addition, current evidence does not sufficiently evaluate the impact of SGLT-2I on reducing liver fat content or histological outcomes. The potential risk of weight gain associated with TZD appears to be a limitation to their use. Vitamin E may be a suitable option for nondiabetic patients with NAFLD.
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Li et al. (2025) studied this question.
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