Enhanced detection of bacterial etiologies, antibiotic resistance profile, and treatment outcomes of meningitis patients in Ethiopia: a prospective cross-sectional study

Key Points

• This research aims to investigate bacterial causes and treatment outcomes in meningitis patients in Ethiopia.
• Conducted a prospective cross-sectional study in Ethiopian healthcare facilities.
• Utilized PCR and culture methods to detect bacterial pathogens in patients.
• Documented antibiotic resistance profiles among Gram-negative bacteria.
• E. coli was the most commonly identified bacterial pathogen causing meningitis.
• PCR significantly outperformed culture in detecting bacterial pathogens.
• High rates of antibiotic resistance were noted among Gram-negative bacteria.
• Favorable outcomes were common, but poor Glasgow Coma Scale scores and comorbidities were linked to unfavorable outcomes.