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December 19, 2025Metabolism and Target Organ DamageOpen Access

Sex and gender differences in MASLD: pathophysiological mechanisms, clinical implications, and future directions

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Authors

MJMohamad JamaliniaSSSamira SaeianNNNima Nikkhoo

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Overview

Narrative review highlights biological sex and socio-behavioral factors in MASLD risk, suggesting improved risk stratification and therapies.

Key Points

  • Assess how sex and gender differences impact metabolic dysfunction-associated steatotic liver disease (MASLD).
  • Narrative review synthesizing existing evidence
  • Examined biological sex effects and socio-behavioral influences
  • Considered sex differences in metabolic phenotypes and comorbidities
  • Identified critical sex and gender determinants of MASLD
  • Highlighted sex-specific effects in diagnoses and therapies
  • Proposed frameworks for improved risk stratification and clinical trials

Cite This Study

Jamalinia et al. (2025) studied this question.

synapsesocial.com/papers/69449a922f0218eca9508663https://doi.org/10.20517/mtod.2025.131
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