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December 19, 2025Metabolism and Target Organ DamageOpen Access

Short-term L-arabinose administration alleviates MASLD by remodeling gut microbiota and activating hepatic ATF5-dependent mitochondrial unfolded protein response

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Authors

HZHeng ZhangRCRong ChenWZWeiwei Zhang

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Overview

Treatment with L-arabinose improves lipid metabolism and reduces oxidative stress in metabolic liver disease, suggesting new therapeutic strategies.

Key Points

  • The study investigates the role of L-arabinose in modulating gut microbiota and hepatic mitochondrial function in MASLD.
  • Established a murine early-stage fatty liver model
  • Administered L-arabinose orally for four weeks
  • Assessed gut microbiota changes via 16S rRNA sequencing
  • Performed ATF5 gain- and loss-of-function experiments in vivo and in vitro
  • L-arabinose administration reshaped gut microbiota, enriching short-chain fatty acid-producing taxa
  • Improved hepatic lipid metabolism through activation of ATF5
  • Enhanced expression of HSP60 and LONP1, initiating the mitochondrial unfolded protein response (UPRmt)
  • Restored mitochondrial integrity and reduced oxidative stress, attenuating hepatic lipid deposition

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69449a922f0218eca95086e3https://doi.org/10.20517/mtod.2025.179
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