Orbital Waldenström Macroglobulinemia With Angiopathic Paraprotein Deposition: A Case Report

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To describe a rare case of orbital infiltration in a patient with Waldenström macroglobulinemia and its ocular effects.
Descriptive case report of a 66-year-old female with WM.
Right orbital biopsy performed to assess infiltration.
IgM immunohistochemistry used to characterize eosinophilic hyaline deposition.
Patient experienced recurrent transient vision loss.
Right orbital biopsy revealed adipose tissue infiltration with eosinophilic hyaline material.
Associated patchy infiltrate of low-grade B-cell lymphoma noted.

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Case report shows vision loss due to orbital infiltration in a patient with Waldenström macroglobulinemia, highlighting unique ocular manifestations.

Ang et al. (2025) studied this question.

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Case report shows vision loss due to orbital infiltration in a patient with Waldenström macroglobulinemia, highlighting unique ocular manifestations.